Helicobacter pylori is a bacterial pathogen that brings about serious disorders, such as gastritis, ulcers and gastric cancer. Though this bacterium continues to be extensively studied, the physiological functions of the massive amount of the proteins encoded by its genome are unknown. HP1028 is directly a protein that's related to colonization and also to the survival with the bacterium while in the stomach, but its function is not really clearly understood. Bioinformatics research recommend that HP1028 is really a monomeric protein that may be secreted in the H. pylori periplasm. The crystal structure of HP1028 has been determined at two.six angstrom resolution applying the Sad system. The three-dimensional framework of the protein Protease reveals that it belongs to the lipocalin family, a group of proteins that bind and transport (normally hydrophobic) tiny molecules. The framework of HP1028, along with the feasible localization of your mature protein during the bacterial periplasm as well as the place of the hp1028 gene within the bacterial genome, stage to a purpose in H. pylori selleck chemical chemotaxis.